Steroid withdrawal syndrome pdf

The most commonly used AAS in medicine are testosterone and its various esters (but most commonly testosterone undecanoate , testosterone enanthate , testosterone cypionate , and testosterone propionate ), [53] nandrolone esters (most commonly nandrolone decanoate and nandrolone phenylpropionate ), stanozolol , and metandienone (methandrostenolone). [1] Others also available and used commonly but to a lesser extent include methyltestosterone , oxandrolone , mesterolone , and oxymetholone , as well as drostanolone propionate , metenolone (methylandrostenolone), and fluoxymesterone . [1] Dihydrotestosterone (DHT; androstanolone, stanolone) and its esters are also notable, although they are not widely used in medicine. [54] Boldenone undecylenate and trenbolone acetate are used in veterinary medicine . [1]

While anabolic steroids can enhance certain types of performance or appearance, they are dangerous drugs, and when used inappropriately they can cause a host of severe, long-lasting, and in some cases, irreversible negative health consequences. Anabolic steroids can lead to early heart attacks, strokes, liver tumors, kidney failure, and serious psychiatric problems. In addition, because steroids are often injected, users who share needles or use nonsterile techniques when they inject steroids are at risk for contracting dangerous infections, such as HIV/AIDS and hepatitis B and C.

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The primary medication used during treatment is methadone . Methadone is a synthetic opiate that reduces the body's need for other opiates. It's been used successfully for several decades as a treatment aid.
Therapeutic treatments include one-on-one counseling and group therapy. The counseling deals with the personal issues of the addict. In counseling, an attempt is made to determine the underlying issues that led to the addiction. Once these issues are found, coping strategies are developed for the addict to deal with them without turning to the opiates for relief. As a support for counseling, groups such as Narcotics Anonymous or Smart Recovery help by providing a counsel of peers to the addict. These peers will help the addict to recognize the pitfalls of recovery, and the actions needed to avoid them.

Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2), [29] the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.

Steroid withdrawal syndrome pdf

steroid withdrawal syndrome pdf

The primary medication used during treatment is methadone . Methadone is a synthetic opiate that reduces the body's need for other opiates. It's been used successfully for several decades as a treatment aid.
Therapeutic treatments include one-on-one counseling and group therapy. The counseling deals with the personal issues of the addict. In counseling, an attempt is made to determine the underlying issues that led to the addiction. Once these issues are found, coping strategies are developed for the addict to deal with them without turning to the opiates for relief. As a support for counseling, groups such as Narcotics Anonymous or Smart Recovery help by providing a counsel of peers to the addict. These peers will help the addict to recognize the pitfalls of recovery, and the actions needed to avoid them.

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