Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
I was put on prednisone for mono 9 days ago with the dose of 10mg tablets. I was also put on clindamycin for 10 days. The directions for the prednisone said take 4 pills a day for 4 days, 2 pills a day for 4 days, 1 pill a day for 4 days and finally 1/2 pill a day for 4 days. The problem is I’m always anxious, have tight muscles especially on my left side, get flushed red like I’m hot but running no fever, my heart rate picks up for time to time, and cannot sleep but want to. Is this the prednisone and if so can I stop using it now cause I’m wearing out not sleeping?