Kortikosteroidima

Considerando os estudos que compararam o tratamento de longa duração com o de curta duração, estudos mais antigos com risco de viés elevado ou incerto tenderam a sobrestimar o efeito da terapêutica de longo duração em comparação com estudos recentes com risco de viés baixo. Estudos com risco de viés baixo não encontraram diferenças significativas no risco de recaída ou de desenvolvimento de síndrome nefrótico recidivante entre a administração de prednisona durante três a seis meses e durante dois a três meses. Neste sentido, não há benefício de aumentar a duração de prednisona além de dois a três meses, em doentes com episódio inicial de síndrome nefrótico sensível aos corticóides.

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.


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ஆதாரத்தின் குறைந்த தரத்தினால், இந்த எண்கள் உண்மையான நன்மைகளை கணிசமான அளவில் அதிகமாக மதிப்பீடு செய்திருக்கலாம் என்பதை கருத்தில் கொள்ள வேண்டும்.

Kortikosteroidima

kortikosteroidima

ஆதாரத்தின் குறைந்த தரத்தினால், இந்த எண்கள் உண்மையான நன்மைகளை கணிசமான அளவில் அதிகமாக மதிப்பீடு செய்திருக்கலாம் என்பதை கருத்தில் கொள்ள வேண்டும்.

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