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Bortezomib is associated with peripheral neuropathy in 30% of patients; occasionally, it can be painful. This can be worse in patients with pre-existing neuropathy . In addition, myelosuppression causing neutropenia and thrombocytopenia can also occur and be dose-limiting. However, these side effects are usually mild relative to bone marrow transplantation and other treatment options for patients with advanced disease. Bortezomib is associated with a high rate of shingles ,  although prophylactic acyclovir can reduce the risk of this.  Acute interstitial nephritis has also been reported. 
The Apex Hydraulics Private Limited , established in 2008 have to their name a long experience in the industry. We come as composers of various premium quality of Industrial and Hydraulic Equipment such as hydraulic presses, hydraulic cylinders, hydraulic test rigs, hydraulic power packs, hydraulic machines, hydraulic test rigs, hydraulic cylinders and hydraulic presses. Additionally, we are also traders of Polyhydron Pumps and Valves, Tube Fittings and Valves, Filters and accessories, and Gear Pumps. Our line-up has application in various rubber, general engineering, and plastic components manufacturing industries. We also have to our name a certain engineering excellence and strong tie-ups with various very popular fabricators who enjoy our factors of customization and configurations.