When lifting weights, muscle fibers are damaged and AA is released. Its release alters local chemistry, which supports a shift that favors anabolism.* The general anabolic cascade begins with the release of AA and is greatly amplified in the presence of more AA. This translates into supporting androgen receptors (increasing testosterone sensitivity), heightened IGF-1 signaling, greater vasodilation and even enhanced lipolysis.* The availability of AA appears to dictate how strongly this anabolic cascade will be stimulated with training.*
Oral intake of cissus quadrangularis (petroleum ether extract of the stem; % yield) in a rat model mimicking menopause (ovarectomized rats) at a dose of 500mg/kg for ninety days is able to fully prevent losses of bone strength and prevent up to 86% of the losses in bone thickness;  cissus quadrangularis showed comparable efficacy to /kg of the SERM known as raloxifene, and while this study is duplciated in Medline  the design has been replicated where a month of cissus quadrangularis supplementation (500mg/kg petroleum ether extract) was comparable in efficacy 25mg/kg raloxifene in ovarectomized rats.